Artery-Dilating Flaxseed Proven A Potent Healer

Artery-Dilating Flaxseed Proven A Potent Healer | flaxseed_heals_arteries | Natural Medicine

A promising new study published in the journal Hypertension titled, “Potent antihypertensive action of dietary flaxseed in hypertensive patients,” reveals that dietary flaxseed may represent a powerful therapeutic intervention in patients with cardiovascular disease.

Canadian researchers at St. Boniface Hospital Research Centre, Winnipeg, conducted a human clinical trial in order to test whether flaxseed would produce measurable improvements in patients with peripheral artery disease (P.A.D), a condition in which atherosclerotic plaque builds up in the arteries that carry blood to the head, organs, and limbs.

The prospective, double-blinded, placebo-controlled, randomized trial, included 110 patients who ingested a variety of foods that contained 30 grams (approximately 4 tablespoons) of milled flaxseed or placebo each day over 6 months. The purpose of their study was to “examine the effects of daily ingestion of flaxseed on systolic (SBP) and diastolic blood pressure (DBP) in peripheral artery disease patients,” as hypertension is commonly associated with P.A.D.

After six months, the results of the dietary intervention were impressive:

  • Blood plasma levels of the omega-3 fatty acid α-linolenic acid and enterolignans increased 2- to 50-fold in the flaxseed-fed group versus the placebo group.
  • Systolic blood pressure (SBP) was ≈ 10 mm Hg lower in the flaxseed group
  • Diastolic blood pressure (DBP) was ≈ 7 mm Hg lower in the flaxseed group

According to the study, “Patients who entered the trial with a SBP ≥ 140 mm Hg at baseline obtained a significant reduction of 15 mm Hg in SBP and 7 mm Hg in DBP from flaxseed ingestion.”

The researchers also found that circulating α-linolenic acid levels correlated with SBP and DBP, and lignan levels correlated with changes in DBP.

The final summary concluded: “[F]laxseed induced one of the most potent antihypertensive effects achieved by a dietary intervention.”

Discussion

Flaxseed’s health benefits are as complex as the components of the remarkable seed itself. Each component, including its fiber, lignans and omega-3 fatty acids, possess unique health benefits. In fact, over the past decade, hundreds of studies have been performed on whole flaxseed and/or its parts, revealing their value in over 100 health conditions. Top on the list of clinically confirmed health benefits are its anti-breast cancer properties, but it also contains the following properties of value in cardiovascular conditions:

  • Cholesterol Modulation: Flaxseed may reduce circulating total and LDL-cholesterol levels,[i] [ii] and prevent LDL cholesterol from oxidizing, which is what renders it atherogenic (heart-disease promoting).[iii]
  • Increased Blood Flow: Flaxseed consumption improves flow-mediated dilation of the arteries (brachial) and reduces blood pressure.[iv]
  • C-reactive Protein Reduction: Elevated C-reactive protein is often a marker for heart disease related inflammation and associated increased risk of cardiovascular events. A flaxseed-derived lignan supplement appears to reduce C-reactive protein in type 2 diabetics – a population a far greater risk for cardiovascular disease and associated events.[v]
  • Plaque Reduction: Dietary flaxseed accelerates the regression of atherosclerotic plaques in the rabbit model.[vi] It is believed that secoisolariciresinol diglucoside (SDG), a phytoestrogen present in flax, is responsible for this anti-atherosclerotic effect.[vii]

Other ways in which flaxseeds confer cardioprotective effects is through their anti-inflammatory activity, largely due to the abundance of omega-3 fatty acids they contain, and their fiber, which improves the elimination of oxidized lipids, cholesterol, fat-soluble toxins and hormone metabolites through its bile-binding action.

For more information on flaxseed’s remarkable heart-friendly properties, read our recent article “Evidence That Flaxseed Is A Heart Disease Reversing Food.”

For additional research on clinically confirmed natural alternatives to blood pressure drugs, read “Garlic Compares Favorably To A Best-Selling Blood Pressure Drug.


[i] An Pan, Danxia Yu, Wendy Demark-Wahnefried, Oscar H Franco, Xu Lin. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009 Aug;90(2):288-97. Epub 2009 Jun 10. PMID: 19515737

[ii] An Pan, Danxia Yu, Wendy Demark-Wahnefried, Oscar H Franco, Xu Lin. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009 Aug;90(2):288-97. Epub 2009 Jun 10. PMID: 19515737

[iii] Rogelio U Almario, Sidika E Karakas. Lignan content of the flaxseed influences its biological effects in healthy men and women. J Am Coll Nutr. 2013 Jun ;32(3):194-9. PMID: 23885993

[iv] Sheila G West, Andrea Likos Krick, Laura Cousino Klein, Guixiang Zhao, Todd F Wojtowicz, Matthew McGuiness, Deborah M Bagshaw, Paul Wagner, Rachel M Ceballos, Bruce J Holub, Penny M Kris-Etherton. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. J Am Coll Nutr. 2010 Dec ;29(6):595-603. PMID: 21677123

[v] An Pan, Wendy Demark-Wahnefried, Xingwang Ye, Zhijie Yu, Huaixing Li, Qibin Qi, Jianqin Sun, Yanqiu Chen, Xiafei Chen, Yong Liu, Xu Lin. Effects of a flaxseed-derived lignan supplement on C-reactive protein, IL-6 and retinol-binding protein 4 in type 2 diabetic patients. Br J Nutr. 2009 Apr;101(8):1145-9. PMID: 18775100

[vi] Andrew A Francis, Justin F Deniset, Jose A Austria, Renee K Lavallee, Graham G Maddaford, Thomas E Hedley, Elena Dibrov, Grant N Pierce. The Effects of Dietary Flaxseed on Atherosclerotic Plaque Regression. Am J Physiol Heart Circ Physiol. 2013 Apr 12. Epub 2013 Apr 12. PMID:23585134

[vii] Kailash Prasad. Natural products in regression and slowing of progression of atherosclerosis. Curr Pharm Biotechnol. 2010 Dec;11(8):794-800. PMID: 20874684

 

© March 30, 2017 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.


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Roundup ‘Weed Killer’ Threatens Coral Reefs, Persists In Seawater

Roundup 'Weed Killer' Threatens Coral Reefs, Persists In Seawater | roundup_coral_reefs1 | Environment Special Interests Toxins

The coral reefs are dying and the seas are increasingly depleted of sea life. Could Roundup ‘weed killer’ be partially to blame?

A highly concerning study published in the journal Marine Pollution Bulletin indicates that the world’s most popular herbicide glyphosate (aka Roundup), used primarily in GM agriculture, is particularly resistant to biodegradation in coral reef collected sea water, and could therefore be a major contributor to the decline of marine coral reef systems such as the Great Barrier Reef.

The Great Barrier Reef is the world’s biggest single structure made by living organisms, and is so massive it is visible from outer space.[i] Sadly, according to a study published in 2012 by the Proceedings of the National Academy of Sciences, the reef has lost more than half its coral cover since 1985,[ii] which is believed to be caused by a combination of factors, including climate change induced acidification of the ocean, outbreaks of predator species and extensive pollution. Despite the established role of agrichemicals in harming sea life, glyphosate has yet to be included in marine monitoring programs for its impacts on the reef — this despite being used at a rate of 30,000,000 lbs annually in Australia.

In the study titled, “Glyphosate persistence in seawater,” Australian marine researchers describe “increasing concern over the global loss of corals and seagrass and this has been particularly well documented for the World Heritage listed Great Barrier Reef (GBR),” pointing out that extensive agriculture activities impact water quality around reefs and seagrass beds, especially during the summer wet season from November to March, when rain-induced flooding delivers “runoff containing excess sediments, nutrients, and pesticides,” and with satellite imagery reveals their associated plumes travel up to 50 km offshore as far as the midshelf coral reefs.

In order to ascertain the potential impact of glyphosate, they quantified its biodegradation using “simulation” flask tests with native bacterial populations and coastal seawater from the Great Barrier Reef. They discovered that, “the half-life for glyphosate at 25°C in low-light was 47 days, extending to 267 days in the dark at 25°C and 315 days in the dark at 31°C, which is the longest persistence reported for this herbicide.”

When compared to previously reported half-life estimates for glyphosate biodegradation in soil and fresh waters, the sea water estimates are dramatically higher. Previous soil and water data described glyphosate’s biodegration half-life to be as rapid as 5 days for field soil and 49 days for bog and natural water.*  If the new sea water flask experiments accurately reflect real world conditions, glyphosate’s maximal 315 day half life in sea water would add up to 63 fold increased persistence to the chemical’s toxicological profile. The researchers also pointed out that flooding events which would bring glyphosate to sea would involve co-occurrence of massive quantities of sediment to which glyphosate readily binds, which would further prevent glyphosate’s biodegradation, potentially greatly enhancing its persistence and toxic effects.

Despite previous assurances by both the manufacturer (Monsanto) and regulatory bodies that glyphosate is safe to the environment and highly biodegradable, an increasingly alarming body of experimental data on glyphosate’s toxicity indicates that the chemical is extremely toxic, exhibiting potentially carcinogenic endocrine disrupting activity in the parts-per-trillion concentration range, as well as a laundry list of multiple modes of toxicity to animal life.  For direct access to the biomedical data on glyphoste’s toxicological profile, view our section on the topic: Glyphosate Toxicity.

*Note: accumulating evidence reveals that these original estimates are inaccurate and that glyphosate’s persistence in the soil, groundwater, and even air, is a far greater problem than officially acknowledged.


[i] Sarah Belfield (8 February 2002). “Great Barrier Reef: no buried treasure”

[ii] Eilperin, Juliet. “Great Barrier Reef has lost half its corals since 1985, new study says”. The Washington Post. Retrieved 1 October 2012

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10 Natural Substances That Could Help Cure Type 1 Diabetes

 10 Natural Substances That Could Help Cure Type 1 Diabetes | spices | Natural Medicine

Could the long-sought after cure for type 1 diabetes be as close as your kitchen cupboard? An accumulating body of scientific research appears to point in exactly that direction.

One so-called ‘incurable disease’ that afflicts millions of people around the world is type 1 diabetes. Unlike type 2 diabetes, where the body becomes resistant to its own insulin, type 1 is characterized by the inability of the body to produce enough insulin, as the beta cells within the pancreas which are responsible for the production of insulin (and the proinsulin from which it is made) are either destroyed or seriously impaired. This can happen due to autoimmune issues, bacterial or viral infections, incompatible foods in the diet and chemical exposures (or a combination of any one or more of these factors), to name but a few major triggers.

And yet, plenty of peer-reviewed and published research now indicates that plant compounds, including many found within commonly consumed foods, are capable of stimulating beta cell regeneration within the pancreas, and as a result may be potentially provide a cure – truly a four letter word, as far as the profit-based model of medicine goes, which thrives on the concept of the incurability of the disease-afflicted human body in favor of symptom management.

The discovery of the beta cell regenerative potential of various food and compounds is bound to upset a burgeoning diabetes industry, with millions of dollars of public and private money continually being poured into fund-raising efforts for a future “cure”; A cure that will presumably be delivered through the prohibitively expensive pharmaceutical,vaccine or biologic (e.g. stem cells, islet cell xenotransplantation) pipeline, which by the very nature of the FDA drug approval process requires the promotion of synthetic (and therefore patentable) compounds over natural ones.

Let’s take a look at the latest preclinical study on the topic, published last month in the Canadian Journal of Physiology and Pharmacology[1]. An active fraction of flaxseed, which researchers named Linun usitassimum active fraction (LU6), was found to generate a wide range of benefits in a type 1 diabetes animal model, including the following:

  • Improved glucose utilization in the liver
  • Supported normalized glycogenesis (glucose forming activity) in the liver and muscle tissue
  • Reduced pancreatic and intestinal glucosidase inhibitory activity, which translates into lower post-meal blood sugar elevations

Even more remarkable was the observation that this flaxseed compound normalized plasma insulin and C-peptide levels (C peptide is not C-reactive protein, rather it is a direct indicator of how much insulin is being produced by the beta cells in the body. Learn more), an indication that beta cell function was effectively restored. The researchers described the truly amazing results as follows:

Normalization of plasma insulin and C-peptide levels were observed in diabetic mice, indicating endogenous insulin secretion after the treatment with LU6. The histochemical and immunohistochemical analysis on pancreatic islets suggests the role of LU6 fraction in islet regeneration and insulin secretion as evident in increase functional pancreatic islets producing insulin. Furthermore, significant insulin producing islet formation was also observed in in vitro PANC-1 cells after LU6 treatment, indicating the cellular aggregates to be newly formed islets. This suggests the potential of LU6 fraction in the formation of new islets in vitro, as well as in vivo. Thus, LU6 can be used as a nutraceutical-based first-line treatment for diabetes. [emphasis added]

Keep in mind that this is not the first time that flaxseed has been found to improve blood sugar disorders. We have a few studies on GreenMedInfo.com already indexed on the topic that you can view here: Flaxseed and Diabetes.

Furthermore, we have found a broad range of natural substances experimentally confirmed to stimulate beta cell regeneration, 10 of which are listed below:

  • Arginine: a 2007 study found that the amino acid L-arginine is capable of stimulating the genesis of beta cells in an animal model of alloxan-induced diabetes.[2]
  • Avocado: A 2007 study found that avocado seed extract reduced blood sugar in diabetic rats. Researchers observed a restorative and protective effect on pancreatic islet cells in the treated group.[3]
  • Berberine: A 2009 study found that this plant compound, commonly found in herbs such as barberry and goldenseal, induces beta cell regeneration in diabetic rats, which lends explanation for why it has been used for 1400 years in China to treat diabetes.[4]
  • Chard: A 2000 study found that chard extract given to diabetic rats stimulates the recovery of injured beta cells.[5]
  • Corn Silk: A 2009 study found that corn silk reduces blood sugar and stimulates beta cell regeneration in type 1 diabetic rats.[6]
  • Curcumin (from Turmeric): A 2010 study found that curcumin stimulates beta cell regeneration in type 1 diabetic rats.[7] Additionally, a 2008 study found that curcumin preserves pancreatic islet cell survival and transplantation efficiency.[8]
  • Genistein (from soy, red clover): A 2010 study found that genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice.[9]
  • Honey: A 2010 human study found that long-term consumption of honey might have positive effects on the metabolic derangements of type 1 diabetes, including possible beta cell regeneration as indicating by increases in fasting C-peptide levels.[10]
  • Nigella Sativa (black seed): A 2003 animal study found that black seed consumption lead to partial regeneration/proliferation of the beta-cells.[11] A 2010 human study also found that the consumption of one gram of black seed a day for up to 12 weeks had a broad range of beneficial effects in diabetics, including increasing beta cell function.[12]
  • Stevia: A 2011 human study found that stevia has anti-diabetic properties, including revitalizing damaged beta cells, and compares favorably with the drug glibenclamide but without the adverse effects.[13]

For a full list of beta cell regenerating substances, view our page on the topic. The data is also available to download as a PDF, which members can acquire by using their membership tokens without paying the nominal fee.

For additional research on the topic of regenerative medicine and diabetes you can consult the articles 6 Bodily Tissues that Can Be Regenerated Through Nutrition and Diabetes: An Entirely Preventable and Reversible Disease. Or, visit our Health Guide on Blood Sugar Disorders.


[2] Ana Vasilijevic, Biljana Buzadzic, Aleksandra Korac, Vesna Petrovic, Aleksandra Jankovic, Bato Korac.Beneficial effects of L-arginine nitric oxide-producing pathway in rats treated with alloxan. J Physiol. 2007 Nov 1;584(Pt 3):921-33. Epub 2007 Aug 23. PMID: 17717015

[4] Jiyin Zhou, Shiwen Zhou, Jianlin Tang, Kebin Zhang, Lixia Guang, Yongping Huang, Ying Xu, Yi Ying, Le Zhang, Dandan Li. Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats. Eur J Pharmacol. 2009 Mar 15;606(1-3):262-8. Epub 2009 Jan 19. PMID: 19374872

[5] S Bolkent, R Yanardağ, A Tabakoğlu-Oğuz, O Ozsoy-Saçan. Effects of chard (Beta vulgaris L. var. Cicla) extract on pancreatic B cells in streptozotocin-diabetic rats: a morphological and biochemical study. J Ethnopharmacol. 2000 Nov;73(1-2):251-9. PMID: 11025163

[6] Jianyou Guo, Tongjun Liu, Linna Han, Yongmei Liu. The effects of corn silk on glycaemic metabolism. Nutr Metab (Lond).2009 Nov 23;6:47. PMID: 19930631

[7] Malee Chanpoo, Hattaya Petchpiboonthai, Busaba Panyarachun, Vipavee Anupunpisit. Effect of curcumin in the amelioration of pancreatic islets in streptozotocin-induced diabetic mice. J Med Assoc Thai. 2010 Nov;93 Suppl 6:S152-9. PMID: 21280528

[9] Zhuo Fu, Wen Zhang, Wei Zhen, Hazel Lum, Jerry Nadler, Josep Bassaganya-Riera, Zhenquan Jia, Yanwen Wang, Hara Misra, Dongmin Liu. Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. 2010 Jul ;151(7):3026-37. Epub 2010 May 19. PMID: 20484465

[10] Mamdouh M Abdulrhman, Mohamed H El-Hefnawy, Rasha H Aly, Rania H Shatla, Rasha M Mamdouh, Doaa M Mahmoud, Waheed S Mohamed. Metabolic Effects of Honey in Type 1 Diabetes Mellitus: A Randomized Crossover Pilot Study. J Med Food. 2012 Dec 20. Epub 2012 Dec 20. PMID:23256446

[11] Mehmet Kanter, Ismail Meral, Zabit Yener, Hanefi Ozbek, Halit Demir. Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku J Exp Med. 2003 Dec;201(4):213-9. PMID:14690013

[12] Abdullah O Bamosa, Huda Kaatabi, Fatma M Lebdaa, Abdul-Muhssen Al Elq, Ali Al-Sultanb. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):344-54. PMID: 21675032

[13] Himanshu Misra, Manish Soni, Narendra Silawat, Darshana Mehta, B K Mehta, D C Jain. Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert. (Bertoni) on alloxan-induced diabetic rats. J Pharm Bioallied Sci. 2011 Apr ;3(2):242-8. PMID: 21687353

 

©  March 29, 2017 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.


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Corporations Replace BPA with More DNA-Damaging Bisphenols

Corporations Replace BPA with More DNA-Damaging Bisphenols | bisphenol_toxicity | Environment General Health Toxins

p in the journal Chemosphere confirms that the hormone-disrupting chemical known as bisphenol A (BPA) is not the only bisphenol with DNA-damaging effects. In fact, the new cell study found that “…bisphenol AP, bisphenol M, or bisphenol P exerted genotoxic potentials that are greater than that of BPA.”

As consumer and regulatory pressure pushes manufacturers to eliminate BPA in favor of ostensibly safer alternatives, some are simply substituting less well known bisphenols into their products and disingenuously labeling them “BPA-free.”  Others are finding truly safer alternatives to bisphenols, but there is too little oversight to know for sure.

The US Food Supply Already Widely Contaminated With Bisphenols

This latest finding brings back to the forefront a concerning discovery made earlier this year that a wide range of bisphenols are already contaminating the US food supply.

The study published in the Journal of Agricultural and Food Chemistry analyzed the concentrations of hormone-disrupting chemicals known as bisphenols in foodstuff from the United States and their implications for human exposure, revealing widespread contamination.[i]

The researchers set out to determine the occurrence of bisphenols, other than BPA, in foodstuffs, due to the fact that information on the topic is scarce.  Their methodology was as follows:

[S]everal bisphenol analogues, including BPA, BPF, and BPS, were analyzed in foodstuffs (N = 267) collected from Albany, New York, USA, using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Foodstuffs were divided into nine categories of beverages, dairy products, fat and oils, fish and seafood, cereals, meat and meat products, fruits, vegetables, and “others.”

The study revealed bisphenol contamination of the US food supply is endemic:

Bisphenols were found in the majority (75%) of the food samples, and the total concentrations of bisphenols (ΣBPs: sum of eight bisphenols) were in the range of below the limit of quantification to 1130 ng/g fresh weight, with an overall mean value of 4.38 ng/g. The highest overall mean concentration of ΣBPs was found in the “others” category, which included condiments [emphasis added]

Within the category of vegetables, a sample of mustard (dressing) and ginger contained the highest concentrations of 1130 ng/g for bisphenol F (BPF) and 237 ng/g for bisphenol P(BPP). This dovetails with two other disturbing findings from last year: 1) human and synthetic hormones now widely contaminate fresh produce2) synthetic hormone activity now eclipses that of natural hormones within exposed populations.

The Journal of Agricultural and Food Chemistry study also found that canned foods contained higher concentrations of individual and total bisphenols in comparison to foods sold in glass, paper, or plastic containers, likely due to the epoxy-resin can liners, which unless explicitly labeled to be ‘bisphenol free’ contain bisphenol

Even with the latest finding on the genotoxicity of bisphenols other than BPA, there still has been little to no adequate toxicological and safety research performed on these relatively novel xenobiotic chemicals, despite the fact that millions of consumers are already being exposed to them.

It was only last year that it became apparent that global manufacturers of consumer goods that formerly used BPA were switching to the equally toxic (and environmentally more persistent) bisphenol BPS. [see: Consumer Alert: BPA-Free Goods Still Contain Toxin Bisphenol.]

BPS is increasingly being used to displace BPA in global paper currency and thermal printer paper, and is now found in human urine samples at levels as high as BPA.  The new study discovered that the second most prevalent  bisphenol analogue found in foodstuffs was BPF, which accounted for 17% of the total BP concentrations versus 42% for BPA.

The study concluded that on the basis of measured concentrations and daily ingestion rates of foods, the daily dietary intake of bisphenols (calculated from the mean concentration) were estimated to be 243,142,177,63.6, and 58.6 ng/kg bw/day for toddlers, infants, children, teenagers, and adults, respectively.

In order to understand how high these levels are, one must compare the disturbing effects of so-called “low-dose” exposure levels in animals.  Two animal studies published in 2005 found that doses as low as 25 ng/kg bw/day resulted in “permanent changes to genital tract,” [ii] and “changes in breast tissue that predispose cells to hormones and carcinogens”[iii]  Based on the study findings, toddlers are being exposed to almost 10 times that amount (243 ng/kg bw/day) through their food alone. This does not even account for many other sources in their environment, including sippy cups, canned foods and formula, etc.

For additional research, including natural strategies to reduce the toxicity of bisphenols and encouraging their detoxification, read the article: Manufacturers Replace BPA with Still Highly Toxic BPS


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© March 28, 2017  GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.


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Long Term Cholesterol Drug Use Doubles Risk of Breast Cancer

Long Term Cholesterol Drug Use Doubles Risk of Breast Cancer | statin-pills | Big Pharma General Health Medical & Health Sleuth Journal

A study published in the journal Cancer Epidemiology, Biomarkers & Prevention indicates that women who are long-term users of statin drugs have between 83-143% increased risk of breast cancer.[1]

The population-based case-control study utilized data from women in the Seattle-Puget Sound region, which included 916 invasive ductal carcinoma (IDC) and 1,068 invasive lobular carcinoma (ILC) cases of 55-74 years of age diagnosed between 2000 and 2008, and a control of 902 women.

Whereas recent publicity on statin drugs has focused on their potential use for cancer prevention or as anti-cancer agents, this study found exactly the opposite with current users of statins for 10 years or longer having a 1.83-fold increased risk of invasive ductal carcinoma (IDC) and a 1.97-fold increased risk of invasive lobular carcinoma (ILC) compared to never users of statins.

Additionally, among women diagnosed with hypercholesterolemia, a condition marked by high levels of lipids and lipoproteins in the blood, current users of statins for 10 years or longer had more than double the risk of both IDC [an average of 104% increased risk] and ILC [an average of 143% increased risk] compared to never users.

Of course, the discovery of a correlation between higher statin drug use and higher breast cancer risk does not necessarily imply causation. For instance, women who are on statins are obviously compliant with conventional blood lipid screening recommendations and therefore are more likely to be complaint with breast screening guidelines as well. Given that recent estimates show that breast screenings have resulted in over 1.3 million US women being misdiagnosed and overtreated for breast cancer in the past 30 years, simply being complaint with breast screening guidelines will result in significantly increased risk of being diagnosed with breast cancer regardless of whether the diagnosis is accurate or not. [2]

On the other hand, this study could indicate a more serious problem, namely, that cholesterol-lowering drugs and statin drugs in particular are carcinogenic. Statin drugs, in fact, have long been suspected to increase the risk of certain cancers, including prostate,[3] colorectal,[4] and kidney;[5] conversely, low cholesterol has been found to increase the risk of cancer at all sites, further implicating these cholesterol-lowering agents as possible carcinogens.[i][6]

At the least, this new study raises doubt as to whether the recent push to identify statin drugs as possible chemopreventive or chemotherapeutic agents can be validated by independent science, especially considering that this class of cholesterol-lowering medications have been linked to over 300 adverse health effects in the published literature.

This latest finding is all the more reason why natural dietary and nutritional interventions should be considered a first line defense against elevated blood lipids, and why the very question of whether cholesterol is a primary contributing factor in heart disease should be examined more carefully.

Learn more at our Health Guides: Statin Drugs and Heart Health.


[1] Jean A McDougall, Kathleen E Malone, Janet R Daling, Kara L Cushing-Haugen, Peggy L Porter, Christopher I Li. Long-term statin use and risk of ductal and lobular breast cancer among women 55-74 years of age. Cancer Epidemiol Biomarkers Prev. 2013 Jul 5. Epub 2013 Jul 5.

[2] GreenMedInfo.com, 30 Years of Breast Screening: 1.3 Million Wrongly Treated, Nov. 2012

[3] Chih-Ching Chang, Shu-Chen Ho, Hui-Fen Chiu, Chun-Yuh Yang. Statins increase the risk of prostate cancer: A population-based case-control study. Prostate. 2011 Dec ;71(16):1818-24. Epub 2011 Apr 7.

[4] Fatim Lakha, Evropi Theodoratou, Susan M Farrington, Albert Tenesa, Roseanne Cetnarskyj, Farhat Vn Din, Mary E Porteous, Malcolm G Dunlop, Harry Campbell. Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage. BMC Cancer. 2012 Oct 22 ;12(1):487. Epub 2012 Oct 22.

[5] Hui-Fen Chiu, Chien-Chun Kuo, Hsin-Wei Kuo, I-Ming Lee, Chien-Te Lee, Chun-Yuh Yang. Statin use and the risk of kidney cancer: a population-based case-control study. Expert Opin Drug Saf. 2012 Jul ;11(4):543-9. Epub 2012 Apr 16.

[6] GreenMedInfo.com, Low Cholesterol Cancer link (8 abstracts)

 

©  March 26, 2017  GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.


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Ibuprofen Can Stop Your Heart (31% Increase In Cardiac Arrest Risk)

Ibuprofen Can Stop Your Heart (31% Increase In Cardiac Arrest Risk) | ibuprofen_cardiac_arrest_greenmedinfo | General Health Sleuth Journal

A new study reveals that a commonly consumed painkiller, wrongly considered “harmless” by millions, is probably causing thousands of deaths from cardiac arrest each year.

According to the Sudden Cardiac Arrest Foundation, sudden cardiac arrest (SCA) is a leading cause of death among adults over 40 in the United States and other countries, with about 326,200 people experiencing an out-of-hospital SCA each year in the US alone; nine of 10 victims of SCA will die.1

Suprisingly, however, the causes of SCA are still widely considered unknown. Instead, the medical profession opts for pointing the finger at vague risk factors, such as family history, previous heart problems, or elevated LDL cholesterol (a long debunked surrogate marker for heart disease].

But what if something so obvious and preventable as the consumption of NSAID drugs could be contributing to this health epidemic?

Ibuprofen Can Stop Your Heart (31% Increase In Cardiac Arrest Risk) | Causes-of-Death-2012 | General Health Sleuth Journal

New Study Reveals Heart-Stopping Side Effects of NSAIDs

In a concerning press release issued by the European Society of Cardiology entitled, “‘HARMLESS’ PAINKILLERS ASSOCIATED WITH INCREASED RISK OF CARDIAC ARREST,”2 researchers warn that painkillers considered harmless by the general public are associated with a significantly increased risk of cardiac arrest.

The report was based on a study entitled, “Non-Steroidal Anti-Inflammatory Drug Use Is Associated With Increased Risk of Out-Of-Hospital Cardiac Arrest: A Nationwide Case-Time-Control Study,” published in the March issue of European Heart Journal – Cardiovascular Pharmacology.

Professor Gunnar H. Gisalson, one of the lead researchers explained in interview:

“Allowing these drugs to be purchased without a prescription, and without any advice or restrictions, sends a message to the public that they must be safe.”

“Previous studies have shown that NSAIDs are related to increased cardiovascular risk which is a concern because they are widely used.”

The study looked at a total of 28,947 patients who experienced an out-of-hospital cardiac arrest in Denmark over the course of a decade. Heart attack differs from cardiac arrest in that the former involves damage to the heart when the blood supply stops (usually through obstruction of circulation), whereas the latter involves damage from the heart itself stopping. 3,376 of these were treated with an non-steroidal anti-inflammatory drug (NSAIDs) up to 30 days before the event. The most common NSAIDs used were ibuprofen (51%) and diclofenac (22%).

The study results revealed that NSAID use was associated with a 31% increased risk of cardiac arrest. Ibuprofen and diclofenac increased the risk by 31% and 50%, respectively. Naproxen, celecoxib and rofecoxib were not associated with increased cardiac arrest.

Gunnar remarked on these findings:

“The findings are a stark reminder that NSAIDs are not harmless. Diclofenac and ibuprofen, both commonly used drugs, were associated with significantly increased risk of cardiac arrest. NSAIDs should be used with caution and for a valid indication. They should probably be avoided in patients with cardiovascular disease or many cardiovascular risk factors.”

This is not the first time that ibuprofen’s profound cardiotoxicity has come to light. We reported on the subject five years ago in an article entitled, Ibuprofen Kills Thousands Each Year, So What Is The Alternative?

We strongly agree with Gunnar’s closing interview remarks when he says:

“The current message being sent to the public about NSAIDs is wrong. If you can buy these drugs in a convenience store then you probably think ‘they must be safe for me’. Our study adds to the evidence about the adverse cardiovascular effects of NSAIDs and confirms that they should be taken seriously, and used only after consulting a healthcare professional.”

Keep in mind that other common pain-killers, such as aspirin and acetaminophen (Tylenol), also have devastating side effects that are commonly underreported or minimized. You can read our previous writings on the topic:

Natural Alternatives That Don’t Have Killer Side Effects Exist

Given the clear evidence that pharmaceutical pain-killers have profound, even life-threatening side effects, natural alternatives should be researched and implemented. At GreenMedInfo.com we have a number of database sections that should help move the paradigm forward.

 

©  March 21, 2017 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.

 


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Sunlight Holds Key To Killing Breast Cancer

Sunlight Holds Key To Killing Breast Cancer | sunlight | Natural Medicine

A new study finds vitamin D — the ‘sunlight vitamin’ — strikes to the very heart of breast cancer malignancy.

Breast cancer is not what most people think. Beneath the intimidating statistics that make it seem like a juggernaut of inevitability or a time bomb of genetic determinism ready to go off in the asymptomatic breasts of millions of women, a far more complex conversation is occurring among clinicians and researchers concerning the true nature and causes of cancer, and why conventional therapies fail to turn the tide against the second highest cause of death in the Western world.  To fully appreciate this, one must go to the first hand research itself.

For instance, a new study published in The Journal of Steroid Biochemistry and Molecular Biology identifies an overlooked root cause of breast cancer (cancer stem cells), as well as a natural intervention that has yet to be incorporated into the conventional standard of cancer care.

Titled, “Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer,” the new study brings to the forefront the role of breast cancer stem cells (BSCs) in breast tumor formation and their progression towards malignancy and treatment resistance. For many decades it was assumed that cancer results from DNA-damaged cells succumbing to fundamentally chaotic processes, ‘going rogue’ and reproducing clonally (making identical copies of one another), without an acknowledgment of the different types of cells that comprise tumors. The most salient difference is between the cancer stem cells (sometimes referred to as ‘mother’ cells) which are capable of theoretically infinite self-renewal and produce all the differentiated ‘daughter’ cells in a tumor colony, which themselves are not capable of living indefinitely. It is actually the existence of the much smaller number of cancer stem cells which causes cancer recurrence, as they are not only resistant to conventional chemotherapy and radiation, but their numbers can actually be increased (enriched) by these two ‘therapies.’ Therefore, any cancer therapy that ignores the cancer stem cell subpopulation in favor of killing the non-tumorigenic daughter cells in order to ‘debulk’ the tumor (i.e. shrink it), will not result in destroying the root of the cancer. To the contrary, it can generate the illusion of ‘remission’ while in fact making the remaining tumor colony far more malignant, setting up the conditions for aggressive recurrence years later.

The new study focused on a type of breast tissue abnormality known as ductal carcinoma in situ (DCIS), which for decades was considered cancer (constituting about 20% of all breast cancer diagnoses), but recently has been identified as a benign lesion of epithelial origin. There are cases where DCIS progresses towards another breast abnormality known as invasive ductal carcinoma (IDC), which is considered a more serious risk. But even IDC cases may never progress to cause symptoms, nor ever cause harm to those within which it occurs. Nonetheless, the conventional medical system still considers a diagnosis of either DCIS or IDC justification for aggressive interventions, e.g. lumpectomy, mastectomy, radiotherapy and chemotherapy, indicating that if there is a natural intervention to decelerate the trajectory from DCIS to IDC, especially if it focuses on targeting and/or reducing the expression and growth of breast cancer stem cells, it is of great clinical relevance.

The new study sought to determine whether vitamin D3 and an analog known as BXL0124 are capable of inhibiting the progression of DCIS to IDC, and whether this effect is mediated through an influence on breast cancer stem cells (BCSCs). The study used a mammosphere cell culture system, which is a clump of mammary gland cells that includes breast cancer stem cells along with non-stem cell breast cells.

The researchers found that when the Vitamin D compounds were administered to the mammosphere culture it was observed to undergo a transition from a state of disorganization and irregularity in shape to a more organized and symmetrical shape similar to spheres formed by a non-malignant, normal mammary epithelial cell line. This cancer-defying effect of the vitamin D compounds was described in terms of a reduction in the so-called ‘mammosphere forming efficiency (MFE).” Moreover, treatment with vitamin D compounds was found to repress cell markers associated with stem cell-like phenotype (e.g. CD44, CD49f,c-Notch1, andpNFkB), as well as pluripotency markers (e.g. OCT4 and KLF-4), another property found within cancer stem cells.

The study concluded:

“Cancer progression, metastasis, and recurrence are significant problems in managing breast cancer. A significant body of evidence indicates that breast cancer stem cells drive these processes, complicating treatment strategies. A better understanding of how BCSCs drive breast cancer progression will aid in developing targeted therapies toward BCSCs. Our present study suggests a potential treatment strategy to reduce the putative BCSC population, and therefore enhance the effectiveness of breast cancer prevention and treatment through the use of vitamin D compounds.” [emphasis added]

Regardless of whether DCIS or ICS really do represent a mortal threat to the health and lives of women, this study indicates that vitamin D targets the most malignant cell type found within breast cancer — the cancer stem cells — which is infinitely more selective an intervention than radiation and chemotherapy; nor does vitamin D have the profoundly damaging side effects of conventional cancer treatment.

Vitamin D, of course, is designed to be manufactured through the ultraviolet B-stimulated conversion of the cholesterol metabolite 7-dehydrocholesterol in the skin. The fact that in the modern era the breasts are never exposed to sunlight and that generally speaking adequate sunlight exposure (especially considering the over-use of vitamin-D blocking and carcinogenic petroleum-based sunscreens) is rare, it is likely that many of the variations in breast morphology increasingly being diagnosed through technologies like mammography as being ‘abnormal’ or ‘precancerous,’ directly reflect a deficiency of sunlight and Vitamin D.  While the U.S. Preventive Task Force does not believe there is enough evidence supporting the benefit of vitamin D screening in routine practice, there is no harm in getting a blood test to determine one’s levels relative to the background population. And since vitamin D3 supplementation is affordable and extremely safe relative to commonly prescribed pharmaceuticals like Tamoxifen (a known carcinogen), it may provide those at risk for breast cancer or breast cancer recurrence with a reasonable alternative to watchful waiting and/or preventive chemotherapy.

For additional research on risk factors for breast cancer stem cell enrichment, as well as natural substances found to kill them, take a look at our database page on the topic: Breast Cancer Stem Cells, as well as the larger database section on Cancer Stem Cells in general.

© March 20, 2017 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.

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Ways To Reduce The Cancer-Causing Effects Of Cell Phones (VIDEO)

Ways To Reduce The Cancer-Causing Effects Of Cell Phones (VIDEO) | cell-phones1 | General Health Multimedia Science & Technology Special Interests

Ever since the World Health Organization admitted in 2011 that cell phone radiation is “possibly carcinogenic,” and may be contributing to the global uptick in brain cancer cases, its far harder to label someone a hypochondriac for being concerned about the health consequences of exposure.[i]  In fact, one study cited in their report showed a 40% increased risk for gliomas in the highest category of heavy users (reported average: 30 minutes per day over a 10-year period) – not exactly a small effect.

A recent study published in the journal Cellular and Molecular Neurobiology confirms that the microwave radiation given off by mobile phones is capable of transforming normal cells into cancerous ones.

Titled “Cellular Neoplastic Transformation Induced by 916 MHz Microwave Radiation,” researchers exposed fibroblast cells, a connective tissue-producing type of cell, to 916 MHz electromagnetic frequencies (which have already been shown to alter brain biomolecules), and found that after 5-8 weeks exposure they changed their form and rate of proliferation to a cancerous phenotype. These cells were also found to be tumor-forming when transplanted into mice.

What You Can Do To Protect Yourself

Realistically, most people reading this article will not be decommissioning their iphones or androids anytime soon. These devices enable us to stay closely connected to our loved ones, as well as to connect to the global brain which is the internet. But what this research does implore us to do is to exercise caution. Here are a few steps to take to reduce exposure:

  • Wear a headset or earphones to keep the device as far away from your head and/or other vital organs as possible.
  • Turn the device off whenever it is not being used.
  • If you are a heavy user, consider incorporating one of the following proven cell-phone radiation mitigating substances:
  • Bee Propolis – A compound found within bee propolis, which is like the mortar the bees use to repair and maintain the structural integrity of their hive, known as caffeic acid phenethyl ester (CAPE), has been experimentally tested to protect the kidneys, hearts and retinas of cell-phone exposed mice.  Our bee propolis research page actually lists 12 studies on its radioprotective properties, including protecting against diagnostic and/or “therapeutic” (e.g. radiotherapy) gamma-radiation.
  • Melatonin – Melatonin is released during deep, restful sleep – which is always the best way to obtain this natural protective secretion. Melatonin has been studied for its ability to protect against cell-phone induced retinal and kidney damage.  Like propolis, melatonin has also been shown to have powerful radioprotective properties against gamma-radiation induced oxidative stress and tissue injury.
  • EGCG (green tea polyphenol) – Green tea contains a potent antioxidant known as EGCG (epigallocatechin-gallate) and which has been shown to protect the liver against mobile-phone induced radiation damage.
  • Ginkgo Biloba – This plant never ceases to amaze. Not only is it the oldest living plant (a “living fossil”) known to man, but it seems to provide a broad range of benefits to brain and cognitive health.  It has been experimentally confirmed to prevent mobile-phone induced oxidative stress in the rat brain.
  • N-acetyl-cysteine (NAC) – NAC is the the precursor to glutathione, a powerful cell-protective antioxidant that your body produces, given it has adequate cofactors available.  It has been shown to protect the liver against mobile-phone induced damage.

For additional tips, read contributing writer, Susan Calabro’s nifty article titled “4-Acupuncture-Inspired Ways to Stop Neurotic Phone Checking

For those interested in learning more about the plausible mechanism through which cell phones cause brain cancer, listen to Dr. Chris Busby’s explanation:

The post Ways To Reduce The Cancer-Causing Effects Of Cell Phones (VIDEO) appeared first on The Sleuth Journal.


Source: Alternative news journal

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Honey and Black Seed Combo Cures 57% of H. Pylori Patients

Honey and Black Seed Combo Cures 57% of H. Pylori Patients | honey | Natural Medicine Special Interests

H. pylori infection may be treated effectively with two ancient food-based remedies, new research suggests.

Natural solutions for H. pylori are gaining increased attention due to the failure of conventional antibiotics to produce a permanent resolution of the condition without attendant adverse effects. In a previous post entitled “3 Natural H. Pylori ‘Cures’ That Are Clinically Proven,” we reported on broccoli sprouts, probiotics, and black seed, as evidence-based natural interventions. Now, a new study published in the International Journal of Antimicrobial Agents reveals that black seed in combination with honey results in the resolution of about 1 in 2 cases of H. pylori infection.

The study entitled, “Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection,” provided background on the increasing problem of antibiotic-resistant cases of H. pylori in the studied Iranian population:

“Owing to the alarming rate of anti-H. pylori drug resistance (14% – 45% for clarithromycin, 40% – 65% for metronidazole, and 2-37% for amoxicillin in Iran), eradication of H. pylori remains a global challenge (2, 5, 6).”

Due to the state of conventional treatment, the authors sought to test “new safe, feasible and affordable alternatives.”

The study design was described as follows:

“Nineteen patients who had positive result for H. pylori infection by urea breath test (UBT) without a past history of peptic ulcer, gastric cancer or gastrointestinal bleeding, were suggested to receive one teaspoon of the mixture of Dosin (6 g/day of N. sativa as ground seeds and 12 g/day of honey) three times a day after meals for two weeks. The second UBT was used to detect the presence of H. pylori four weeks after completion of the test. In addition, symptoms of dyspepsia were scored before and after the study and analyzed with Wilcoxon signed-rank test.”

The results were reported as follows:

“Fourteen patients completed the study. Negative UBT was observed in 57.1% (8/14) of participants after intervention. The median and interquartile range (IQR) of total dyspepsia symptoms was significantly reduced from 5.5 (5 – 12) to 1 (0 – 4) (P = 0.005). All the patients tolerated Dosin except for one who was excluded due to mild diarrhea. No serious adverse events were reported.”

These results are remarkable when you consider that two previous studies using conventional antibiotics, also conducted on Iranian population, resulted in slightly lower rates of eradication. The first which involved the use of 4 drugs  (omeprazole, amoxicillin, each administered twice daily for the first five days, followed by omeprazole, clarithromycin and furazolidone, twice daily for the remaining nine days) resulted in eradication in 50.9% of patients. The second study, which used 4 drugs, (omeprazole, clarithromycin, amoxicillin and bismuth twice daily for 14 days) resulted in 49.1% reduction.

The researchers also pointed out that even though their combination of honey and black seed may not eradicate H. pylori in all cases, it has a palliative effect in gastrointestinal symptoms in non-ulcer dyspepsia. This is likely not true for conventional antibiotics which may have a wide range of adverse effects related to the depopulation of beneficial gut bacteria. In fact, we recently reported on the use of a special form of honey to treat one of the most common and deadly forms of antibiotic-related infections, namely , C. difficile. Learn more: Exotic Honey Comes To Rescue In Fighting Deadly C. Difficile

To learn more about natural H. pylori eradication therapies view our database on the topic: Helicobacter Pylori research.

© March 17, 2017 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.

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Source: Alternative news journal

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Broccoli Can Stimulate Brain Regeneration, New Research Suggests

Broccoli Can Stimulate Brain Regeneration, New Research Suggests | broccoli | Natural Medicine Science & Technology Sleuth Journal Special Interests

For decades it was believed that brain regeneration was not possible. But an accumulating body of research now reveals that common foods such as broccoli contain compounds capable of stimulating the repair and renewal of nerve tissue.

Ever since Santiago Ramón y Cajal, the father of neuroscience, declared “nothing may be regenerated” in the adult brain, the idea that you can repair or regenerate damaged brain tissue was precluded by this central dogma. But compelling evidence for brain regeneration began to surface in the 1960’s with a report by MIT scientist Joseph Altman that the hippocampus of adult rats and guinea pigs and the cortex of cats indeed underwent a process termed neurogenesis,1  i.e. the growth and development of nervous tissue.

In the decades that followed, more and more evidence began to amass showing the brain is in a continually dynamic state of self-repair and self-regeneration, relying on neural stem cells to replace and repair damaged and aged tissue. Clearly, in an era of widespread neurodegenerative disease which the conventional medical establishment claims are incurable, this discovery is encouraging. If the brain can regenerate, the the key is to find out how to prevent interference with this process and/or ascertain methods to increase and support its innate self-healing capacity.

In a previous report, we looked at research on a compound found in turmeric known as aromatic-tumerone. This fat soluble component appears to be an ideal candidate for enhancing the brain’s natural regenerative process. Learn more by reading How WHOLE Turmeric Heals The Damaged Brain.

But this is just scratching the surface. We have indexed over 45 natural substances with putative neuritogenic properties which can be viewed here: Pharmacological Action: Neuritogenic.

The newest addition to this list is sulforophane, an incredibly powerful sulfur-containing biomolecule found in cruciferous vegetables. Our sulforophane database contains research on its potential therapeutic value in about 200 different conditions. You can read our recent review on this amazing healing food component here: Top 10 Reasons to Eat Your Cruciferous Veggies.

Now, a new study published in the journal Genesis entitled, “Effects of sulforaphane on neural stem cell proliferation and differentiation,” reveals that sulforaphane may have significant ameliorative properties against the underlying pathological disturbances found in common neurodegenerative diseases such as increased oxidative stress, inflammation, perturbed calcium homeostasis, and neuronal death.  The authors of the study theorized that sulforaphane may mitigate these factors, along with stimulating neural stem cells (NSC) activity. An already robust body of literature exists indicating that sulforaphane has the following beneficial pharmacological actions:

  • Up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), which increases innate antioxidant mechanisms.
  • Suppressing of interleukin-1b (IL-1b), to exert its anti-inflammatory effects.

In contradistinction, the new study sought to evaluate if sulforphane is capable of protecting, and regulating neural stem cells in such a way as to confer neuroprotective properties. It also sought to determine if sulforophane’s therapeutic properties depend in some way on its Wnt signaling properties, which has been identified as a key molecular pathway involved in tissue regeneration.

The Promising Study Results

First, the researchers determined the optimal concentration range of sulforophane in promoting neural stem cell (NSC) growth without harming neurons. The researchers determined that “Concentrations of less than 5 mM did not induce cytotoxic effects, but rather potentially promote the growth of NSCs.”

Second, the researchers determined that sulforophane indeed modified genes in the WnT signaling pathway.

Finally, the researchers determined that exposing NSCs to sulforaphane resulted in their differentiation to neurons, lending powerful support to the hypothesis that sulforaphane could stimulate brain repair.

The researchers concluded:

“In summary, we demonstrated that the crucifer-derived SFN can effectively stimulate NSC proliferation and differentiation by modifying genes in Wnt signaling pathway. Due to its lipophilic property and low molecular weight, SFN has a high bioavailability as an orally administered drug (Houghton, Fassett, & Coombes, 2013). SFN represents a food-derived compound that has been successfully translated from lab bench to clinics. (Bahadoran et al., 2012). It can be expected that SFN would see a shorter clinical path toward the market. Our data indicate that SFN is not only an Nrf2 inducer, but also a Wnt activator, which places SFN in a category distinct from other phytochemicals. The effects of SFN in restoring Wnt signaling provides a wealth of opportunities for the treatment of stem-cell-related diseases characterized by suppressed Wnt signaling. Further clinical studies are warranted to corroborate the neuroprotective effects of SFN in patients.”

I believe this research provides compelling evidence that the consumption of sulforophane-containing foods may have therapeutic value in brain degenerative disorders. Considering that sulforophane is a naturally occurring biomolecule which has been part of the human diet since time immemorial, it is likely that its regular consumption via culinary practices delivers physiologically significant quantities in a delivery system — food — that is safe and effective in the prevention of disease. Also, it is an astounding feature of this biomolecule that it has been identified to have potential value in preventing and/or treating about 200 different health conditions. This means that the side benefits of consuming it are orders of magnitude higher than one would anticipate if one were simply looking to consume it for one specific concern. That’s the amazing thing about healing with whole foods: their health benefits are too vast to bottle-neck into simply one or two applications.

What is the best way to obtain sulforphane?

While all Cruciferous vegetables contains significant amounts of sulforaphane, the sprouts of broccoli have several orders of magnitude higher concentratiuons of sulforaphane versus the mature broccoli plant, gram-per-gram. Learn more by watching the informative video below:

Additional References

Feb. 2012, The Guardian: Does your brain produce new cells?

 

© March 16, 2017 GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.

The post Broccoli Can Stimulate Brain Regeneration, New Research Suggests appeared first on The Sleuth Journal.


Source: Alternative news journal

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